Reaktion #219039

Reaktionsgleichung

(4-aminophenyl)acetic acid ethyl ester

cyclopentanecarbonitrile

(4-amino-3-cyclopentanecarbonylphenyl)acetic acid ethyl ester

2-aminothiazole

→

(4-Amino-3-cyclopentanecarbonylphenyl)acetic acid ethyl ester

[3-Cyclopentanecarbonyl-4-(3-thiazol-2-yl-ureido)phenyl]acetic acid ethyl ester

Reaktionsbedingungen

Vorschrift

(4-Amino-3-cyclopentanecarbonylphenyl)acetic acid ethyl ester (2.7 g) is prepared from (4-aminophenyl)acetic acid ethyl ester (18.0 g, 0.1 mol) and cyclopentanecarbonitrile (9.5 g, 0.1 mol) following the general procedure I. [3-Cyclopentanecarbonyl-4-(3-thiazol-2-yl-ureido)phenyl]acetic acid ethyl ester (140 mg) is prepared from (4-amino-3-cyclopentanecarbonylphenyl)acetic acid ethyl ester (138 mg, 0.5 mmol) and 2-aminothiazole (0.060 g, 0.6 mmol) following the general procedure D.

Quelle