Reaktion #2190328

Reaktionsgleichung

2,2-bis-(3,5-difluoro-phenyl)-benzo[1,3]dioxole-5-carboxylic acid ethyl ester

NaOH

→

white crystals

Ausbeute 81.9%

2,2-bis-(3,5-difluoro-phenyl)-benzo[1,3]dioxole-5-carboxylic acid

Ausbeute 81.9%

Lösungsmittel

ethyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated
2. 2
   SonstigePurification on silica gel

Vorschrift

267 mg 2,2-bis-(3,5-difluoro-phenyl)-benzo[1,3]dioxole-5-carboxylic acid ethyl ester, 3.8 mL ethyl alcohol and 0.96 mL 1N NaOH were stirred at room temperature for 6 h. The solvent was evaporated and the residue worked up with ethyl acetate, diluted hydrochloric acid and water. Purification on silica gel afforded 204 mg white crystals, m.p.: 96° C.; MS: 389 ([M−H]−).

Quelle