Reaktion #219031

Reaktionsgleichung

2-(2-pyridylsulfanyl)aniline

2-mercaptopyridine

2-fluoronitrobenzene

2-(2-pyridylsulfanyl)aniline

2-aminothiazole

→

2-(2-Pyridylsulfanyl)nitrobenzene

Ausbeute 60.0%

N-[2-(2-Pyridylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea

Ausbeute 60.0%

Reaktionsbedingungen

Vorschrift

2-(2-Pyridylsulfanyl)nitrobenzene (0.70 g, 60%) was prepared from 2-mercaptopyridine (0.61 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2-pyridylsulfanyl)aniline (0.37 g, 62%) following general procedure B. N-[2-(2-Pyridylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (98 mg, 60%) was prepared from 2-(2-pyridylsulfanyl)aniline (101 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Quelle