Reaktion #219014

Reaktionsgleichung

2-(2,3-dimethoxyphenoxy)-4-fluoroaniline

2,3-dimethoxyphenol

2,4-difluoro-1-nitrobenzene

2-(2,3-dimethoxyphenoxy)-4-fluoroaniline

2-aminothiazole

→

2-(2,3-Dimethoxyphenoxy)-4-fluoro-1-nitrobenzene

Ausbeute 60.0%

N-[2-(2,3-dimethoxyphenoxy)-4-fluorophenyl]-N′-(thiazol-2-yl)urea

Ausbeute 60.0%

Reaktionsbedingungen

Vorschrift

2-(2,3-Dimethoxyphenoxy)-4-fluoro-1-nitrobenzene (0.88 g, 60%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 2,4-difluoro-1-nitrobenzene (0.8 g, 5.0 mmol) following the general procedure F. This compound was reduced to 2-(2,3-dimethoxyphenoxy)-4-fluoroaniline (0.52 g, 66%) following the general procedure C. N-[2-(2,3-dimethoxyphenoxy)-4-fluorophenyl]-N′-(thiazol-2-yl)urea (116 mg, 60%) was prepared from 2-(2,3-dimethoxyphenoxy)-4-fluoroaniline (132 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Quelle