Reaktion #2186196

Reaktionsgleichung

1-(2-Fluoro-ethyl)-7-hydroxy-1,2,3,4-tetrahydro-quinoline-6-carbaldehyde

(6-chloro-imidazo[1,2-a]pyridin-2-yl)-acetic acid methyl ester

piperidine

→

desired product

Ausbeute 67.4%

3-(6-Chloro-imidazo[1,2-a]pyridin-2-yl)-8-(2-fluoro-ethyl)-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one

Ausbeute 67.4%

Lösungsmittel

benzene

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 18 h
2. 2
   Sonstigeto reach room temperature
3. 3
   Filtrationthe precipitate filtered
4. 4
   Waschenwashed with acetonitrile
5. 5
   Sonstigedried under high vacuum

Vorschrift

200 mg (0.896 mmol) 1-(2-Fluoro-ethyl)-7-hydroxy-1,2,3,4-tetrahydro-quinoline-6-carbaldehyde and 201 mg (1 eq.) (6-chloro-imidazo[1,2-a]pyridin-2-yl)-acetic acid methyl ester in 6 mL benzene and 3 mL acetonitrile are treated with 0.177 mL (2 eq.) piperidine and refluxed for 18 h. The reaction mixture is allowed to reach room temperature and the precipitate filtered, washed with acetonitrile and dried under high vacuum to yield 240 mg (67%) of desired product as a yellow powder.

Quelle