Reaktion #2186192

Reaktionsgleichung

3-Piperazin-1-yl-phenol

1-bromo-2-fluoroethane

→

desired product

Ausbeute 48.0%

3-[4-(2-Fluoro-ethyl)-piperazin-1 -yl]-phenol

Ausbeute 48.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto reach room temperature
2. 2
   Sonstigeevaporated
3. 3
   Sonstigethe residue column chromatographed (silica gel, ethyl acetate/petroleum ether 9:1)

Vorschrift

1 g (5.61 mmol) 3-Piperazin-1-yl-phenol and 0.5 mL (1.25 eq) 1-bromo-2-fluoroethane are stirred 20 h at 60° C. in 5 mL DMF, the reaction mixture allowed to reach room temperature and evaporated, and the residue column chromatographed (silica gel, ethyl acetate/petroleum ether 9:1) to yield 600 mg (48%) of the desired product as a brown oil.

Quelle