Reaktion #2183915

ord-6e321f5337174cdea272b05915cf420d

Reaktionsgleichung

CC(C(=O)c1ccc2c(c1)N(C)C(=O)CO2)c1ccc(Br)cc1Cl
6-[2-(4-bromo-2-chloro-phenyl)-propionyl]-4-methyl-4H-benzo[1,4]oxazin-3-one
C[Si](C)(C)C(F)(F)F
(trifluoromethyl)trimethylsilane
C[N+](C)(C)C.[F-]
tetramethylammonium fluoride
→
CC(c1ccc(Br)cc1Cl)C(O)(c1ccc2c(c1)N(C)C(=O)CO2)C(F)(F)F
title compound
CC(c1ccc(Br)cc1Cl)C(O)(c1ccc2c(c1)N(C)C(=O)CO2)C(F)(F)F
6-[2-(4-Bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-4-methyl-4H-benzo[1,4]oxazin-3-one

Edukte

CC(C(=O)c1ccc2c(c1)N(C)C(=O)CO2)c1ccc(Br)cc1Cl
6-[2-(4-bromo-2-chloro-phenyl)-propionyl]-4-methyl-4H-benzo[1,4]oxazin-3-one
C[Si](C)(C)C(F)(F)F
(trifluoromethyl)trimethylsilane
C[N+](C)(C)C.[F-]
tetramethylammonium fluoride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to Example 1, step 3, 6-[2-(4-bromo-2-chloro-phenyl)-propionyl]-4-methyl-4H-benzo[1,4]oxazin-3-one was reacted with (trifluoromethyl)trimethylsilane and tetramethylammonium fluoride to give the title compound as an off-white solid. MS (m/e, ISP neg. ion)=475.9 [M−H+].

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08450313B2uspto-grants-2013_05