Reaktion #218390

ord-8da8319e6c514501ae60adf844824330

Reaktionsgleichung

O=C(O)COc1ccccc1
phenoxyacetic acid
CC(C)N=C=NC(C)C
diisopropylcarbodiimide
C=CCOC(=O)c1ccc(N(Cc2ccc(OC(F)(F)F)cc2)C(=O)OC(C)(C)C)c(N)c1
3-amino-4-[tert-butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-benzoic acid allylester
→
C=CCOC(=O)c1ccc(N(Cc2ccc(OC(F)(F)F)cc2)C(=O)OC(C)(C)C)c(NC(=O)COc2ccccc2)c1
4-[tert-Butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-3-(2-phenoxy-acetylamino)-benzoic acid allyl ester

Edukte

O=C(O)COc1ccccc1
phenoxyacetic acid
CC(C)N=C=NC(C)C
diisopropylcarbodiimide
C=CCOC(=O)c1ccc(N(Cc2ccc(OC(F)(F)F)cc2)C(=O)OC(C)(C)C)c(N)c1
3-amino-4-[tert-butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-benzoic acid allylester

Reagenzien

Keine

Lösungsmittel

ClCCl
methylenchloride

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    ExtraktionThe product was extracted from methylenchloride/water without further characterization

Vorschrift

318 mg of phenoxyacetic acid were dissolved in methylenchloride and 0.36 ml of diisopropylcarbodiimide added. 950 mg of 3-amino-4-[tert-butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-benzoic acid allylester were added and the reaction mixture stirred at room temperature for 16 h. The product was extracted from methylenchloride/water without further characterization.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07384945B2uspto-grants-2008_06