Reaktion #2180255

Reaktionsgleichung

Methyl chloroformate

N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide

→

title compound

Methyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carboxylate

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction mixture
2. 2
   SonstigeReaction mixture
3. 3
   Einengenwas concentrated
4. 4
   workup.ADDITIONdiluted with water
5. 5
   Extraktionextracted with dichloromethane
6. 6
   Waschenwashed with brine solution
7. 7
   Trocknendried over anhydrous Na2SO4
8. 8
   EinengenConcentrated
9. 9
   Sonstigepurified by column chromatography

Vorschrift

Methyl chloroformate (1.0 mmol) was added drop wise to N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide obtained from step VIII of example 1 (1.0 mmol) solution in 10 mL of dry DMF at 0° C. Reaction mixture was stirred for additional 3 h Reaction mixture was concentrated, diluted with water, extracted with dichloromethane, washed with brine solution, and dried over anhydrous Na2SO4. Concentrated and purified by column chromatography to get the title compound.

Quelle