Reaktion #2180253

Reaktionsgleichung

Triethyl amine

N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide

4-Methyl-benzenesulfonyl chloride

→

title compound

N-(2-aminophenyl)-5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrahydro[1,3]-thiazolo[5,4-c]pyridine-2-carboxamide

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction mixture
2. 2
   Sonstigewas brought to room temperature
3. 3
   SonstigeReaction mixture
4. 4
   Einengenwas concentrated
5. 5
   workup.ADDITIONdiluted with water
6. 6
   Extraktionextracted dichloromethane
7. 7
   Waschenwashed with brine solution
8. 8
   Trocknendried over anhydrous Na2SO4
9. 9
   EinengenConcentrated
10. 10
    Sonstigepurified by column chromatography

Vorschrift

Triethyl amine (1.0 eq) was added to solution of N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide obtained in step VIII of example I (1.0 mmol) in 10 mL THF. The solution was cooled to 0° C. 4-Methyl-benzenesulfonyl chloride (1.0 mmol) was added slowly with continuous stirring. Reaction mixture was brought to room temperature and stirred for 2 h Reaction mixture was concentrated, diluted with water, extracted dichloromethane, washed with brine solution, and dried over anhydrous Na2SO4. Concentrated and purified by column chromatography to yield the title compound.

Quelle