Reaktion #2179464

Reaktionsgleichung

2,3-Dihydro-1H-inden-5-amine

4-chloro-8-iodo-7-methylquinazoline

IPA

→

N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride

Ausbeute 87.0%

Lösungsmittel

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA precipitate formed
2. 2
   Temperaturupon cooling
3. 3
   Filtrationfiltered
4. 4
   Waschenwashed twice with EtOAc (20 mL)
5. 5
   Sonstigeair-dried

Vorschrift

2,3-Dihydro-1H-inden-5-amine (109 mg, 821 μmol), 4-chloro-8-iodo-7-methylquinazoline (250 mg, 821 μmol) and IPA (5 mL) were added to microwave-vial. The reaction mixture was heated at 110° C. for 10 min. A precipitate formed upon cooling. The crude product was diluted with EtOAc (20 mL), filtered, washed twice with EtOAc (20 mL) and air-dried to give N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride (311 mg, 87%) as an amorphous off-white solid. MS (M+H)+ 402.

Quelle