Reaktion #2178585

Reaktionsgleichung

Water

5-fluoro-3-methyl-1-benzofuran

isobutyryl chloride

aluminum chloride

→

title compound

Ausbeute 66.0%

1-(5-fluoro-3-methyl-1-benzofuran-2-yl)-2-methylpropan-1-one

Ausbeute 66.0%

Lösungsmittel

nitromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat room temperature for 12 hr
2. 2
   Extraktionthe mixture was extracted with ethyl acetate
3. 3
   WaschenThe organic layer was washed with saturated brine
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   FiltrationAfter filtration
6. 6
   Einengenthe filtrate was concentrated

Vorschrift

To a solution of 5-fluoro-3-methyl-1-benzofuran (2.0 g) synthesized in Example A67(2) and isobutyryl chloride (1.56 g) in nitromethane (40 mL) was added aluminum chloride (anhydrous) (2.66 g) at 0° C., and the mixture was stirred at 0° C. for 1 hr, and at room temperature for 12 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated. The residue was subjected to silica gel column chromatography (hexane-ethyl acetate 100:0-90:10, v/v) to give the title compound (1.933 g, 66%) as a colorless oil.

Quelle