Reaktion #2178325

Reaktionsgleichung

ethyl 3-{methyl[(4-{[1-(3-methyl-1-benzofuran-2-yl)-2-phenoxyethyl]amino}phenyl)carbonyl]amino}propanoate

tetrahydrofuran

sodium hydroxide

→

compound

Ausbeute 70.4%

3-{methyl[(4-{[1-(3-methyl-1-benzofuran-2-yl)-2-phenoxyethyl]amino}phenyl)carbonyl]amino}propanoic acid

Ausbeute 70.4%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated under reduced pressure
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water (10 mL)
3. 3
   workup.ADDITION1N hydrochloric acid (1.00 mL) was added at 0° C
4. 4
   FiltrationThe resulting precipitate was collected by filtration

Vorschrift

To a mixture of ethyl 3-{methyl[(4-{[1-(3-methyl-1-benzofuran-2-yl)-2-phenoxyethyl]amino}phenyl)carbonyl]amino}propanoate (82.5 mg) synthesized above, tetrahydrofuran (5 mL) and ethanol (5 mL) was added 1N aqueous sodium hydroxide solution (1.00 mL), and the mixture was stirred at room temperature for 5 hr, and concentrated under reduced pressure. The residue was dissolved in water (10 mL), and 1N hydrochloric acid (1.00 mL) was added at 0° C. The resulting precipitate was collected by filtration to give the title object compound (54.8 mg, 70%) as a white solid.

Quelle