Reaktion #2178274

Reaktionsgleichung

2-Ethyl-1-(5-fluoro-3-methyl-1-benzofuran-2-yl)butan-1-one

sodium tetrahydroborate

Water

→

title compound

Ausbeute 106.9%

2-ethyl-1-(5-fluoro-3-methyl-1-benzofuran-2-yl)butan-1-ol

Ausbeute 106.9%

Lösungsmittel

methanol

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added at 0° C
2. 2
   Extraktionthe mixture was extracted with ethyl acetate
3. 3
   WaschenThe organic layer was washed with saturated brine
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   FiltrationAfter filtration
6. 6
   Einengenthe filtrate was concentrated

Vorschrift

2-Ethyl-1-(5-fluoro-3-methyl-1-benzofuran-2-yl)butan-1-one (15.0 g) synthesized above was dissolved in a mixed solvent of methanol (50 mL)-tetrahydrofuran (250 mL), and sodium tetrahydroborate (90%, 5.1 g) was added at 0° C. The reaction mixture was stirred at 0° C. for 1.5 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to give the title compound (16.17 g, 100%) as a colorless oil.

Quelle