Reaktion #217807

Reaktionsgleichung

water

4-pentafluorosulfanylthiophenol

methyl 4-bromo-5-methanesulfonyl-2-methylbenzoate

K2CO3

→

colorless foam

Ausbeute 59.0%

Methyl 5-methanesulfonyl-2-methyl-4-(4-pentafluorosulfanylphenyl-sulfanyl)benzoate

Ausbeute 59.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted twice with 100 ml of EA each time
2. 2
   WaschenThe EA phase was then washed twice with 30 ml of water each time
3. 3
   TrocknenThe residue after drying over MgSO4 and removal of the solvent in vacuo
4. 4
   Sonstigewas chromatographed on silica gel with CH2Cl2/DIP 1:2

Vorschrift

0.28 g of 4-pentafluorosulfanylthiophenol, 0.36 g of methyl 4-bromo-5-methanesulfonyl-2-methylbenzoate and 0.33 g of K2CO3 were dissolved in 8 ml of anhydrous DMF and stirred at 110° C. for 2 h. The reaction mixture was then poured into 100 ml of water and extracted twice with 100 ml of EA each time. The EA phase was then washed twice with 30 ml of water each time. The residue after drying over MgSO4 and removal of the solvent in vacuo was chromatographed on silica gel with CH2Cl2/DIP 1:2. 320 mg of a colorless foam were obtained.

Quelle