Reaktion #217761

Reaktionsgleichung

methyl 5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylate

NaOH

HCl

→

2,4-dioxo-3-azaspiro[5,5]undecane

Ausbeute 68.5%

Lösungsmittel

ethanol water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeare placed in a 250 ml flask
2. 2
   Sonstigeequipped with mechanical agitator
3. 3
   TemperaturThe mixture is heated
4. 4
   Temperaturunder reflux for 1.5 hours
5. 5
   Temperaturheated
6. 6
   Temperaturunder reflux for 3 hours
7. 7
   Sonstigeis formed which
8. 8
   Filtrationis filtered off
9. 9
   Waschenwashed with water
10. 10
    Sonstigedried under vacuum

Vorschrift

10 g of methyl 5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylate and 5 g of NaOH dissolved in 125 ml of 2:1 ethanol/water are placed in a 250 ml flask equipped with mechanical agitator, thermometer and condenser. The mixture is heated under reflux for 1.5 hours, acidified with 5% HCl to pH 2 and heated under reflux for 3 hours. By cooling to 20° C. a precipitate is formed which is filtered off, washed with water and dried under vacuum. 4.7 g of 2,4-dioxo-3-azaspiro[5,5]undecane are obtained.

Quelle