Reaktion #217760

Reaktionsgleichung

benzyl 5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylate

ethyl acetate

→

5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid

Ausbeute 99.7%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with a magnetic stirrer
2. 2
   Filtrationthe mixture is filtered through celite
3. 3
   SonstigeThe solvent is evaporated at 20° C. under reduced pressure

Vorschrift

1.8 g of benzyl 5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylate, 25 ml of ethyl acetate and 0.09 g of 5% Pd/C are placed in a 100 ml flask equipped with a magnetic stirrer, thermometer and condenser. The mixture is stirred for 4 hours at 12° C. under a hydrogen atmosphere. 10 ml methanol are added and the mixture is filtered through celite. The solvent is evaporated at 20° C. under reduced pressure to obtain 1.32 g of 5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid.

Quelle