Reaktion #217757

Reaktionsgleichung

cyclohexylidenecyanoacetamide

sodium

ethanol

sodium

HCl

diethylmalonate

→

ethyl 5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with a magnetic stirrer
2. 2
   SonstigeThe solid obtained
3. 3
   Filtrationis filtered off
4. 4
   Sonstigedried under vacuum

Vorschrift

0.69 g of sodium metal are suspended in 30 ml of anhydrous ethanol in a 100 ml flask equipped with a magnetic stirrer, thermometer and condenser, in a nitrogen atmosphere. When the sodium has dissolved, 4.8 g of diethylmalonate are added followed, after 15 minutes, by 4.92 g of cyclohexylidenecyanoacetamide. The mixture is left for 1 hour under agitation at 25° C. and then acidified with 36% HCl. The solid obtained is filtered off and dried under vacuum. 6.84 g of ethyl 5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylate are obtained.

Quelle