Reaktion #217633

Reaktionsgleichung

4-bromo-N-[5-(cis-3,5-dimethyl-1-piperazinyl)-2-(methyloxy)phenyl]benzenesulfonamide

{3-[(methyloxy)methyl]phenyl}boronic acid

potassium tert-butoxide

→

title compound

N-[5-(cis-3,5-Dimethyl-1-piperazinyl)-2-(methyloxy)phenyl]-3′-[(methyloxy)methyl]-4-biphenylsulfonamide

Lösungsmittel

DME

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting mixture was then evaporated
2. 2
   Sonstigepurified by SCX

Vorschrift

To a mixture of 4-bromo-N-[5-(cis-3,5-dimethyl-1-piperazinyl)-2-(methyloxy)phenyl]benzenesulfonamide (E106) (100 mg, 0.22 mmol) and {3-[(methyloxy)methyl]phenyl}boronic acid (75 mg, 0.45 mmol) in DME (3 ml) was added potassium tert-butoxide (220 mg, 1.96 mmol) and tetrakis(triphenylphosphine)palladium(0) (15 mg, 0.01 mmol) in water (1 ml) and the resulting mixture stirred in a microwave (set at high absorbance) at 100° C. for 30 minutes. The resulting mixture was then evaporated and purified by SCX followed by mass directed autoprep HPLC to afford the title compound (E117). MS (ES+) m/e 496 [M+H]+.

Quelle