Reaktion #2175905

ord-b0626daba0fe42d19f59e25de4583afb

Reaktionsgleichung

COc1ccccc1-c1ccnc(Cl)n1
2-chloro-4-(2-methoxy-phenyl)-pyrimidine
Nc1cccc(CS(N)(=O)=O)c1
(3-amino-phenyl)-methanesulfonamide
COc1ccccc1-c1ccnc(Nc2cccc(CS(N)(=O)=O)c2)n1
{3-[4-(2-methoxy-phenyl)-pyrimidin-2-ylamino]-phenyl}-methanesulfonamide

Lösungsmittel

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe solvent was removed under reduced pressure

Vorschrift

A solution of 2-chloro-4-(2-methoxy-phenyl)-pyrimidine (0.882 g, 0.004 mol), and (3-amino-phenyl)-methanesulfonamide (0.865 g, 0.005 mol) in DMF (12 ml) was stirred for 2 hours at 80° C. (TLC control). The solvent was removed under reduced pressure to afford {3-[4-(2-methoxy-phenyl)-pyrimidin-2-ylamino]-phenyl}-methanesulfonamide.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08436007B2uspto-grants-2013_05