Reaktion #2175463

Reaktionsgleichung

sodium disulfite

sodium cyanide

4-trifluoroethoxycyclohexanone

→

1-Hydroxy-4-trifluoroethoxycyclohexanecarbonitrile

Lösungsmittel

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONare then added dropwise
2. 2
   Temperaturwith cooling at 25-30° C. over a period of 30 min
3. 3
   workup.STIRRINGthe mixture is stirred at room temperature
4. 4
   ExtraktionThe aqueous phase is extracted 3× with in each case 90 ml of toluene
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

13.74 g of sodium cyanide are dissolved in 200 ml of water. Over a period of 30 min, 50 g of 4-trifluoroethoxycyclohexanone are then added dropwise at 20-28° C. with slight cooling. The mixture is stirred at 25° C. for 5 minutes, and 31.48 g of sodium disulfite, dissolved in 100 ml of water, are then added dropwise with cooling at 25-30° C. over a period of 30 min. With monitoring by thin-layer chromatography, the mixture is stirred at room temperature. The aqueous phase is extracted 3× with in each case 90 ml of toluene. The organic phases are combined and concentrated under reduced pressure.

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