Reaktion #2175462

Reaktionsgleichung

methyl methanethiolsulfonate

sodium carbonate

mercaptopentanoic acid

4-Mercapto-4-methylpentanoic acid

methyl methanethiolsulfonate

→

product 8

Ausbeute 70.0%

4-Methyl-4-(methyldithio)pentanoic acid

Ausbeute 70.0%

Lösungsmittel

ethanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added to the acid at a rate that would not
2. 2
   SonstigeThe flask was equipped with a 100 mL addition funnel
3. 3
   TemperaturThe flask was cooled in an ice/water bath
4. 4
   Temperaturthe system was maintained under an argon atmosphere
5. 5
   SonstigeThe cooling bath was removed
6. 6
   SonstigeSolvent was removed by rotary evaporation under vacuum, until approximately 20 mL
7. 7
   workup.ADDITIONAfter which 10 mL of saturated sodium bicarbonate and 30 mL of deionized water were added
8. 8
   WaschenThe mixture was washed three times with 25 mL portions of ethyl acetate in a separatory funnel
9. 9
   Extraktionwas extracted twice with 120 mL portions of ethyl acetate
10. 10
    Waschenwashed with 20 mL of a solution
11. 11
    TrocknenThe organic layer was then dried over 14 g of anhydrous sodium sulfate and solvent
12. 12
    Sonstigewas removed by rotary evaporation under vacuum

Vorschrift

A solution of mercaptopentanoic acid 7 (6.0 mL, 40 mmol) was dissolved in 50 mL of deionized water in a 250 mL flask. The solution was magnetically stirred as sodium carbonate (6.4 g, 60 mmol) was added to the acid at a rate that would not cause excessive frothing. The flask was equipped with a 100 mL addition funnel, which was charged with a solution of methyl methanethiolsulfonate (7.5 g, 60 mmol) dissolved in 30 mL of glass-distilled 100% ethanol. The flask was cooled in an ice/water bath and the system was maintained under an argon atmosphere. The methyl methanethiolsulfonate solution was added drop-wise to the flask as rapidly as possible but without causing excessive frothing. The cooling bath was removed and the reaction mixture was allowed to stir for an additional 3 hours. Solvent was removed by rotary evaporation under vacuum, until approximately 20 mL remained. After which 10 mL of saturated sodium bicarbonate and 30 mL of deionized water were added. The mixture was washed three times with 25 mL portions of ethyl acetate in a separatory funnel. The aqueous layer was adjusted to approximately pH 2 with 5 M HCl and was extracted twice with 120 mL portions of ethyl acetate. The organic layers were combined and washed with 20 mL of a solution composed of saturated NaCl and 1 M HCl at a ratio of 4:1. The organic layer was then dried over 14 g of anhydrous sodium sulfate and solvent was removed by rotary evaporation under vacuum to give 5.4 g of product 8 (70% yield). The material can be taken to the next step without further purification. 1H NMR (CDCl3): δ1.54 (6H, s), 2.15-2.21 (2H, m), 2.64 (3H, s), 2.69-2.72 (2H, m). MS (M+Na+) calc.: 217.0, found: 217.1.

Quelle