Reaktion #2175458

Reaktionsgleichung

9-formyl-2,7-fluorenedicarboxylic acid

sodium borohydride

→

9-hydroxymethyl-2,7-fluorenedicarboxylic acid

Lösungsmittel

water

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto react for two hours
2. 2
   SonstigeThe reaction was quenched with the careful addition of 1 M HCl until acidic
3. 3
   ExtraktionThe product was extracted with ethyl acetate
4. 4
   Trocknendried over sodium sulfate
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated to dryness

Vorschrift

A small sample of 9-formyl-2,7-fluorenedicarboxylic acid (5-10 mg) was dissolved in water with a small amount of THF. An excess amount of sodium borohydride was added and allowed to react for two hours. The reaction was quenched with the careful addition of 1 M HCl until acidic. The product was extracted with ethyl acetate, dried over sodium sulfate, filtered and evaporated to dryness. 1H-NMR (CD3OD): δ (ppm) 8.4 (s, 2H, Ar); 8.2 (m, 2H, Ar); 8.0 (m, 2H, Ar); 4.2 (t, 1H, CH); 4.0 (d, 2H, CH2).

Quelle