Reaktion #2175419

Reaktionsgleichung

1-bromo-2,4-difluorobenzene

N,N′-dimethyl-ethylenediamine

NaO-t-Bu

→

N-(2,4-difluoro-phenyl)-N,N′-dimethylethylenediamine

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturHeat at 110° for 18 h
2. 2
   Temperaturto cool
3. 3
   Extraktionextract with 1N HCl
4. 4
   Extraktionextract with CH2Cl2
5. 5
   SonstigeDry
6. 6
   Einengenconcentrate
7. 7
   Sonstigepurify by PLC

Vorschrift

Combine 1-bromo-2,4-difluorobenzene (1.00 g, 5.18 mmol), N,N′-dimethyl-ethylenediamine (2.74 g, 31.1 mmol), NaO-t-Bu (0.70 g, 7.2 mmol), Pd(dba)2 (0.060 g, 0.10 mmol) and (±)-BINAP (0.19 g, 0.31 mmol) in toluene (10 ml). Heat at 110° for 18 h, allow to cool, and extract with 1N HCl. Basify the aqueous solution with NaOH and extract with CH2Cl2. Dry, concentrate, and purify by PLC to give N-(2,4-difluoro-phenyl)-N,N′-dimethylethylenediamine.

Quelle