Reaktion #2172771

Reaktionsgleichung

5-bromo-3,3-dimethyl-7-hexanoyl-2,3-dihydrobenzofuran

dichloromethane

trifluoroacetic acid

triethyl silane

Intermediate 52

5-bromo-3,3-dimethyl-7-hexanoyl-2,3-dihydrobenzofuran

→

title compound

5-Bromo-3,3-dimethyl-7-hexyl-2,3-dihydro-benzofuran

Lösungsmittel

hexane

ethyl acetate

Reaktionsbedingungen

Vorschrift

Following General Procedure J and using 5-bromo-3,3-dimethyl-7-hexanoyl-2,3-dihydrobenzofuran (Intermediate 52, 0.325 g, 1.0 mmol), trifluoroacetic acid (0.31 mL, 4 mmol), triethyl silane (0.64 mL, 4 mmol) and dichloromethane (5 mL) followed by flash column chromatography using 2% ethyl acetate in hexane as the eluent, the title compound was obtained (0.20 g, 64% for 2 steps).

Quelle