Reaktion #2170667

ord-0743607b52094d85a46a0c8038040359

Reaktionsgleichung

CC1(C2CCCC2)Cc2cc(S)c(Cl)c(Cl)c2C1=O
2-cyclopentyl-2-methyl-5-mercapto-6,7-dichloro-1-indanone
O=C([O-])[O-].[K+].[K+]
potassium carbonate
CCOC(=O)CBr
ethyl bromoacetate
→
CC1(C2CCCC2)Cc2cc(SCC(=O)O)c(Cl)c(Cl)c2C1=O
(1-Oxo-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanylthio)acetic acid

Edukte

CC1(C2CCCC2)Cc2cc(S)c(Cl)c(Cl)c2C1=O
2-cyclopentyl-2-methyl-5-mercapto-6,7-dichloro-1-indanone
O=C([O-])[O-].[K+].[K+]
potassium carbonate
CCOC(=O)CBr
ethyl bromoacetate

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

(1-Oxo-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanylthio)acetic acid is prepared following substantially the same procedure described in Example 10, Step F, using the following substances: 2-cyclopentyl-2-methyl-5-mercapto-6,7-dichloro-1-indanone (3.47 g., 0.01 mole), DMF (40 ml.), potassium carbonate (2.78 g., 0.02 mole) and ethyl bromoacetate (2.9 g., 0.02 mole).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04085219uspto-grants-1978_04