Reaktion #217011

Reaktionsgleichung

2-ethynylpyridine

ethyl diazoacetate

→

5-(2-pyridinyl)pyrazole-3-carboxylic acid ethyl ester

Ausbeute 45.2%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe residue recrystallized with ethanol (50ml)

Vorschrift

A mixture of 2-ethynylpyridine (10.3 g), ethyl diazoacetate (11.6 g), and toluene (100 ml) was stirred at 85° C. for 36 hours. The resulting mixture was rotavaped and the residue recrystallized with ethanol (50ml) to afford 9.81 g of 5-(2-pyridinyl)pyrazole-3-carboxylic acid ethyl ester as tan crystallines, mp 103°-105° C. NMR: 1.43 (t, 3H), 4.40 (q, 2H), 7.32 (s, 1H, 4-pyrazolyl H), 7.30, 7.78, 8.66 (3 m, 4H, pyridinyl H's).

Quelle