Reaktion #216908

Reaktionsgleichung

3-acetylpyridine

L-cysteine

water

→

2-methyl-2-(3-pyridyl)thiazolidine-4- carboxylic acid

Ausbeute 37.8%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 24 hours
2. 2
   EinengenThe reaction mixture was concentrated under reduced pressure, isopropanol
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   Filtrationthe resultant powder was collected by filtration
5. 5
   workup.ADDITIONEthanol was added to the powder
6. 6
   Filtrationthe insoluble matter was filtered off
7. 7
   Einengenthe filtrate was concentrated to dryness
8. 8
   workup.DISSOLUTIONThe residue was dissolved in water
9. 9
   workup.ADDITIONadjusted to pH 6 by addition of diluted hydrochloric acid under ice cooling
10. 10
    Filtrationthe resultant powder was collected by filtration
11. 11
    Waschenwashed with ethanol
12. 12
    Sonstigedried

Vorschrift

A mixture of 3.63 g of 3-acetylpyridine, 3.63 g of L-cysteine, 25 ml of water and 25 ml of ethanol was refluxed for 24 hours. The reaction mixture was concentrated under reduced pressure, isopropanol was added to the residue, and the resultant powder was collected by filtration. Ethanol was added to the powder, the insoluble matter was filtered off, and the filtrate was concentrated to dryness. The residue was dissolved in water and adjusted to pH 6 by addition of diluted hydrochloric acid under ice cooling and stirring, and the resultant powder was collected by filtration, washed with ethanol and dried to give 2.54 g of 2-methyl-2-(3-pyridyl)thiazolidine-4- carboxylic acid.

Quelle