Reaktion #216906

Reaktionsgleichung

Pyridine-4-carbaldehyde

L-cysteine

charcoal

→

2-(4-pyridyl)-thiazolidine-4-carboxylic acid

Ausbeute 57.1%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas warm
2. 2
   FiltrationThe mixture was filtered
3. 3
   TemperaturAfter cooling
4. 4
   Filtrationthe resultant crystalline precipitate was collected by filtration
5. 5
   Waschenwashed with ethanol

Vorschrift

Pyridine-4-carbaldehyde (1.07 g) and 1.21 g of L-cysteine were heated in 60% ethanol at a refluxing temperature for 4 hours. Activated charcoal (100 mg) was added to the reaction mixture while it was warm. The mixture was filtered. After cooling, the resultant crystalline precipitate was collected by filtration and washed with ethanol to give 1.2 g of 2-(4-pyridyl)-thiazolidine-4-carboxylic acid. Melting point 171°-173° C.

Quelle