Reaktion #2168844

Reaktionsgleichung

Cyanogen bromide

compound

tetradecanoic acid hydrazide

→

2-amino-5-tridecyl-1,3,4-oxadiazole

Lösungsmittel

dioxane water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was refluxed for 1 hour
2. 2
   Temperaturto cool
3. 3
   Filtrationfiltered
4. 4
   Waschenwashed with dioxane/water (1:1, 20 mL)
5. 5
   Trocknenwater (50 mL), and dried in vacuo
6. 6
   SonstigeThe solid was recrystallized from chloroform
7. 7
   Sonstigeto yield 4.16 g, m.p. 147°-150° C.

Vorschrift

Cyanogen bromide (2.9 g, 0.027 mol) was added to a mixture of the compound prepared in Step 1 above (6.1 g, 0.025) and KHCO3 (2.8 g, 0.028 mol) in dioxane/water (1:1, 50 mL) at room temperature. The mixture was refluxed for 1 hour, allowed to cool, filtered, washed with dioxane/water (1:1, 20 mL), then water (50 mL), and dried in vacuo. The solid was recrystallized from chloroform to yield 4.16 g, m.p. 147°-150° C.

Quelle