Reaktion #2168750

ord-53c5f25db787484e8ca58115c1e6fee3

Reaktionsgleichung

CC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2C[C@@H]4C)CCN1
(+)-8-fluoro-2-(S)-methyl-9-(3-methyl-1-piperazinyl)-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid
CS(=O)(=O)O
methanesulfonic acid
→
CC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2C[C@@H]4C)CCN1.CS(=O)(=O)O
title compound
CC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2C[C@@H]4C)CCN1.CS(=O)(=O)O
(+)-8-fluoro-2-(S)-methyl-9-(3-methyl-1-piperazinyl)-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid methanesulfonate

Edukte

CC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn4c3c2C[C@@H]4C)CCN1
(+)-8-fluoro-2-(S)-methyl-9-(3-methyl-1-piperazinyl)-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid
CS(=O)(=O)O
methanesulfonic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONtreated in a manner analogous to Example 21

Vorschrift

(+)-8-fluoro-2-(S)-methyl-9-(3-methyl-1-piperazinyl)-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid and methanesulfonic acid were used, and treated in a manner analogous to Example 21, to give the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05185337uspto-grants-1993_02