Reaktion #216691

Reaktionsgleichung

4-piperdine ethanol

sodium hydrogencarbonate

benzyloxycarbonyl chloride

→

captioned compound

Ausbeute 65.0%

1-Benzyloxycarbonyl-4-(2-hydroxyethyl)piperidine

Ausbeute 65.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas gradually dropped under ice-
2. 2
   Temperaturcooling conditions
3. 3
   ExtraktionThe reaction solution was extracted with chloroform
4. 4
   Trocknendried with anhydrous magnesium sulfate
5. 5
   FiltrationThe sulfate was filtered off
6. 6
   workup.DISTILLATIONthe solvent was distilled off

Vorschrift

50 g of 4-piperdine ethanol and 49.2 g of sodium hydrogencarbonate were dissolved in 480 ml of water, in which 55.2 ml of benzyloxycarbonyl chloride was gradually dropped under ice-cooling conditions, followed by agitation for 1 hour as it is. The reaction solution was extracted with chloroform and dried with anhydrous magnesium sulfate. The sulfate was filtered off and the solvent was distilled off, after which the resultant residue was subjected to silica gel column chromatography (developing solvent: ethyl acetate:hexane=30:70) to obtain 66.0 g of the captioned compound (yield:65%).

Quelle