Reaktion #216539

Reaktionsgleichung

Dodecanoyl chloride

2,4,6-triiodophenol

→

ester

Ausbeute 83.1%

2,4,6-Triiodophenyl dodecanoate

Ausbeute 83.1%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was heated under argon for 24 hrs
2. 2
   TemperaturThe reaction mixture was cooled
3. 3
   Waschenwashed with saturated aqueous sodium bicarbonate
4. 4
   TrocknenThe organic layer was dried over magnesium sulfate
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated to dryness under vacuum
7. 7
   Sonstigeto give an off-white solid
8. 8
   SonstigeThe crude product was recrystallized from methanol

Vorschrift

Dodecanoyl chloride (2.95 ml, 12.8 mmol) was added to a suspension of 2,4,6-triiodophenol (6.0 g, 12.7 mmol) in refluxing acetonitrile (50 ml) and the mixture was heated under argon for 24 hrs. The reaction mixture was cooled and washed with saturated aqueous sodium bicarbonate. The organic layer was dried over magnesium sulfate, filtered, and evaporated to dryness under vacuum to give an off-white solid. The crude product was recrystallized from methanol to give 6.9 g (83%) of the desired ester, mp 68°-69° C.

Quelle