Reaktion #216430

Reaktionsgleichung

2-aminoethyl thioalaninate dihydrochloride

thre

ammonia

→

2-amino N-(2-mercaptoethyl) propionamide

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting solution is evaporated to dryness under reduced pressure
2. 2
   SonstigeThe insoluble ammonium chloride is separated by filtration on fritted glass
3. 3
   SonstigeThe filtrate is evaporated to dryness
4. 4
   Sonstigedried under a vacuum at 50° C

Vorschrift

To a suspension of 22.1 g of the 2-aminoethyl thioalaninate dihydrochloride (0.1 mole), obtained above, in 50 cm3 of isopropanol, thre are slowly added, under an inert atmosphere, 20.4 cm3 (0.15) mole) of a 2.5% aqueous ammonia solution. The resulting solution is evaporated to dryness under reduced pressure. The residue is taken up in 100 cm3 of ethanol. The insoluble ammonium chloride is separated by filtration on fritted glass. The filtrate is evaporated to dryness and dried under a vacuum at 50° C. 17.5 g of 2-amino N-(2-mercaptoethyl) propionamide in the form of a white solid whose melting point is 141° C. are obtained.

Quelle