Reaktion #216332

ord-c64ffbda8b5e4e06b75d832b2a52c435

Reaktionsgleichung

C[C@H](O)[C@@]1(c2ccc(F)cc2F)CO1
(1S)-1-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol
O=c1[nH]ccn1-c1ccc(OCC(F)(F)C(F)(F)F)cc1
1-[4-(2,2,3,3,3-pentafluoropropoxy)phenyl]-2(1H,3H)-imidazolone
→
C[C@@H](n1ccn(-c2ccc(OCC(F)(F)C(F)(F)F)cc2)c1=O)[C@@]1(c2ccc(F)cc2F)CO1
1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(2,2,3,3,3-pentafluoropropoxy)phenyl]-2(1H,3H)-imidazolone
Ausbeute 22.0%

Edukte

C[C@H](O)[C@@]1(c2ccc(F)cc2F)CO1
(1S)-1-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol
O=c1[nH]ccn1-c1ccc(OCC(F)(F)C(F)(F)F)cc1
1-[4-(2,2,3,3,3-pentafluoropropoxy)phenyl]-2(1H,3H)-imidazolone

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In the same manner as in Reference Example 5, starting from 1.0 g of (1S)-1-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 1.23 g of 1-[4-(2,2,3,3,3-pentafluoropropoxy)phenyl]-2(1H,3H)-imidazolone, 0.43 g of 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(2,2,3,3,3-pentafluoropropoxy)phenyl]-2(1H,3H)-imidazolone was obtained as colorless plates.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05466820uspto-grants-1995_11