Reaktion #216142

Reaktionsgleichung

Ethyl 2-chloro-6-fluoro-benzimidate

triethylamine

1-methylcyclohexylcarbonyl chloride

→

ethyl N-(1-methylcyclohexylcarbonyl)-2-chloro-6-fluorobenzimidate

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirred at room temperature for 1 hour
2. 2
   SonstigeFurther, it is reacted at 80°-100° C. for 16 hours
3. 3
   SonstigeAfter the completion of the reaction
4. 4
   Waschenthe reaction solution is washed with a saline solution and further with water
5. 5
   Trocknenthe resulting toluene layer is dried on sodium sulfate
6. 6
   Einengenconcentrated

Vorschrift

Ethyl 2-chloro-6-fluoro-benzimidate (1.61 g) and triethylamine (1.0 g) are dissolved in toluene (100 ml), to which is added dropwise 1-methylcyclohexylcarbonyl chloride (1.5 g) at 5°-10° C. with stirring and thereafter stirred at room temperature for 1 hour. Further, it is reacted at 80°-100° C. for 16 hours. After the completion of the reaction, the reaction solution is washed with a saline solution and further with water and then the resulting toluene layer is dried on sodium sulfate and concentrated to obtain crude product of ethyl N-(1-methylcyclohexylcarbonyl)-2-chloro-6-fluorobenzimidate.

Quelle