Reaktion #2161300

Reaktionsgleichung

4-(4-fluorophenyl)-1-[1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl]butane-1,3-dione

NH2NH2.H2O

→

title compound

Ausbeute 86.0%

4-[5-(4-fluorobenzyl)-1H-pyrazol-3-yl]-1-(4-methoxybenzyl)-1H-1,2,3-triazole

Ausbeute 86.0%

Lösungsmittel

EtOH AcOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was evaporated
2. 2
   Waschenthe residue washed with anhydrous Et2O (4×5 mL)
3. 3
   Sonstigethe resulting precipitate was dried in oven

Vorschrift

To a mixture of 4-(4-fluorophenyl)-1-[1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl]butane-1,3-dione (0.6 g, 1.6 mmol) and anhydrous EtOH/AcOH (20 mL/5 mL) was added dropwise NH2NH2.H2O (1.0 mL, 9.6 mmol) at 0° C. and the mixture was stirred at RT overnight. The mixture was evaporated, the residue washed with anhydrous Et2O (4×5 mL) and the resulting precipitate was dried in oven to yield the title compound (0.5 g, 84.0%) as a yellow solid.

Quelle