Reaktion #2161294

Reaktionsgleichung

tert-butyl [5-(4-fluorobenzyl)-3-(1-trityl-1H-imidazol-4-yl)-1H-pyrazol-1-yl]acetate

TFA

→

title compound

Ausbeute 83.3%

[5-(4-fluorobenzyl)-3-(1H-imidazol-4-yl)-1H-pyrazol-1-yl]acetic acid

Ausbeute 83.3%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the addition
2. 2
   SonstigeThe solvent was removed in vacuo
3. 3
   Waschenthe residue was washed with Et2O (3×10 mL)
4. 4
   Sonstigedried in oven

Vorschrift

To a solution of tert-butyl [5-(4-fluorobenzyl)-3-(1-trityl-1H-imidazol-4-yl)-1H-pyrazol-1-yl]acetate (0.5 g, 0.80 mmol) in CH2Cl2 (10 mL) was added dropwise TFA (10 mL) at 0° C. After the addition, the mixture was stirred at 0° C. for 2 hours. The solvent was removed in vacuo and the residue was washed with Et2O (3×10 mL) and dried in oven to yield the title compound (0.2 g, 80.0%) as a white solid.

Quelle