Reaktion #2161293

Reaktionsgleichung

4-(4-fluorophenyl)-1-(1-trityl-1H-imidazol-4-yl)butane-1,3-dione

NH2NH2.H2O

→

title compound

Ausbeute 73.5%

5-(4-fluorobenzyl)-3-(1-trityl-1H-imidazol-4-yl)-1H-pyrazole

Ausbeute 73.5%

Lösungsmittel

EtOH AcOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the addition
2. 2
   SonstigeThe solvent mixture was evaporated
3. 3
   Waschenthe residue washed with anhydrous Et2O (4×250 mL)
4. 4
   Sonstigethe resulting precipitate was dried in oven

Vorschrift

To a mixture of 4-(4-fluorophenyl)-1-(1-trityl-1H-imidazol-4-yl)butane-1,3-dione (80 g, 0.165 mol) and anhydrous EtOH/AcOH (400 mL/100 mL) was added NH2NH2.H2O (80 mL, 0.96 mol) dropwise at 0° C. After the addition, the mixture was stirred at RT overnight. The solvent mixture was evaporated, the residue washed with anhydrous Et2O (4×250 mL) and the resulting precipitate was dried in oven to yield the title compound (58.8 g, 73.0%) as a yellow solid.

Quelle