Reaktion #2161292

Reaktionsgleichung

methyl (4-fluorophenyl)acetate

1-(1-trityl-1H-imidazol-4-yl)ethanone

NaH

→

title compound

Ausbeute 48.9%

4-(4-fluorophenyl)-1-(1-trityl-1H-imidazol-4-yl)butane-1,3-dione

Ausbeute 48.9%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was refluxed overnight
2. 2
   SonstigeThe mixture was evaporated
3. 3
   Sonstigethe residue was purified via column chromatography (silica gel, EtOAc/Petroleum ether 1:5)

Vorschrift

To a solution of 1-(1-trityl-1H-imidazol-4-yl)ethanone (1.5 g, 4.26 mmol) in anhydrous THF (25 mL) was added NaH (0.23 g, 8.52 mmol) at 0° C. The mixture was stirred at RT for 2 hours, and methyl (4-fluorophenyl)acetate (1.43 g, 12.78 mmol) was added at 0° C. The mixture was refluxed overnight. The mixture was evaporated and the residue was purified via column chromatography (silica gel, EtOAc/Petroleum ether 1:5) to yield the title compound (1.018 g, 48.0%) as colorless oil.

Quelle