Reaktion #2161291

Reaktionsgleichung

1-(1-trityl-1H-imidazol-4-yl)ethanol

→

title compound

Ausbeute 100.4%

1-(1-trityl-1H-imidazol-4-yl)ethanone

Ausbeute 100.4%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was refluxed for 2 hours
2. 2
   Sonstigewas consumed completely
3. 3
   Filtrationthe mixture was filtered
4. 4
   WaschenThe filter cake was washed with dry CH2Cl2 (5×50 mL)
5. 5
   Sonstigethe filtrate was evaporated

Vorschrift

To a solution of 1-(1-trityl-1H-imidazol-4-yl)ethanol (4.0 g, 11.3 mmol) in anhydrous 1,4-dioxane (150 mL) was added activated MnO2 (2.5 g, 28.2 mmol) at 0° C. The mixture was refluxed for 2 hours. TLC (EtOAc/Petroleum ether 1:2) showed the starting material was consumed completely, and the mixture was filtered. The filter cake was washed with dry CH2Cl2 (5×50 mL) and the filtrate was evaporated to afford the title compound (4.0 g, 100%) as a white solid.

Quelle