Reaktion #2161261

Reaktionsgleichung

2,4,6-trichloropyrimidine

diethylamine

triethylamine

→

(2,6-Dichloro-pyrimidin-4-yl)-diethyl-amine

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was then concentrated
2. 2
   workup.ADDITION25 mL of CH2Cl2 and 25 mL of water were added
3. 3
   SonstigeThe organic layer was separated
4. 4
   Extraktionthe aqueous layer was extracted by additional amount of dichloromethane (2×10 mL)
5. 5
   Trocknendried over anhydrous Na2SO4
6. 6
   Einengenconcentrated
7. 7
   SonstigeColumn chromatography on silica gel afforded 1.48 g (62%) of L as colorless solid

Vorschrift

To a stirred solution of 2.0 g (10.90 mmols) of 2,4,6-trichloropyrimidine in 25 mL of anhydrous ethanol at 0° C., was added drop wise a solution 0.79 g (10.90 mmols) of diethylamine in 5 mL of ethanol. This was followed by the addition of 2.3 mL (16.35 mmols) of triethylamine and the mixture was stirred for further 30 min. The mixture was then concentrated and 25 mL of CH2Cl2 and 25 mL of water were added. The organic layer was separated and the aqueous layer was extracted by additional amount of dichloromethane (2×10 mL) and the extracts were combined, dried over anhydrous Na2SO4 and concentrated. Column chromatography on silica gel afforded 1.48 g (62%) of L as colorless solid.

Quelle