Reaktion #2161255

Reaktionsgleichung

4-(trifluoromethoxy)phenyl isocyanate

ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigesynthesis in analogy to Example 4A step 3
2. 2
   FiltrationThe reaction mixture is filtered
3. 3
   Einengenthe filtrate is concentrated in vacuo
4. 4
   Sonstigepurified chromatographically

Vorschrift

Under argon, 1.46 g (7.21 mmol) of 4-(trifluoromethoxy)phenyl isocyanate are added to 1.22 g (3.61 mmol) of ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (synthesis in analogy to Example 4A step 3, or also according to Tetrahedron Lett. 2003, 44, 1607 and the literature cited therein) in 50 ml of THF, and the mixture is stirred at room temperature overnight. The reaction mixture is filtered and the filtrate is concentrated in vacuo and purified chromatographically.

Quelle