Reaktion #2161253

Reaktionsgleichung

cyclohexane ethyl acetate

potassium carbonate

iodomethane

ethyl 4-nitro-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Filtrationthe mixture is filtered
3. 3
   Waschenthe residue is washed with dichloromethane
4. 4
   SonstigeThe solid obtained
5. 5
   Sonstigeis dried in vacuo

Vorschrift

6.80 g (36.7 mmol) of ethyl 4-nitro-1H-imidazole-2-carboxylate are dissolved in 140 ml of acetone, and 11.2 g (80.8 mmol) of potassium carbonate and 4.57 ml (73.5 mmol) of iodomethane are added. The mixture is then stirred at 60° C. for 4 h. According to TLC (cyclohexane/ethyl acetate 2:1), the starting material has been converted completely. After cooling, the mixture is filtered, the residue is washed with dichloromethane and the filtrate is freed from the solvent. The solid obtained is dried in vacuo.

Quelle