Reaktion #2161251

Reaktionsgleichung

ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate

hydrogen

→

Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst is filtered off
2. 2
   Einengenthe filtrate is concentrated in vacuo
3. 3
   SonstigeThe concentration residue is directly used further for the next reaction

Vorschrift

3.89 g (16.26 mmol) of ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate are dissolved in 50 ml of THF, and a spatula tip of Raney nickel is added. In a hydrogenation apparatus, the reaction mixture is hydrogenated with hydrogen at room temperature. The catalyst is filtered off and the filtrate is concentrated in vacuo. The concentration residue is directly used further for the next reaction.

Quelle