Reaktion #2161248

Reaktionsgleichung

ammonium formate

ethyl 1-benzyl-1H-imidazole-2-carboxylate

ammonium formate

→

Ethyl imidazole-2-carboxylate

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is heated
2. 2
   Temperaturunder reflux for about 6 h
3. 3
   TemperaturAfter cooling
4. 4
   Filtrationthe catalyst is filtered off
5. 5
   Einengenthe filtrate is concentrated in vacuo
6. 6
   SonstigeThe product that crystallizes out during this operation
7. 7
   Sonstigeis triturated with 80 ml of ice-water
8. 8
   Filtrationcollected by suction filtration

Vorschrift

34.7 g (150.9 mmol) of ethyl 1-benzyl-1H-imidazole-2-carboxylate are dissolved in 1005 ml of ethanol, and 34 g of ammonium formate are added. The reaction mixture is heated under reflux for about 6 h. A total of 8 g of 10% palladium-on-carbon and 18 g of ammonium formate are thereby added in small portions. After cooling, the catalyst is filtered off and the filtrate is concentrated in vacuo. The product that crystallizes out during this operation is triturated with 80 ml of ice-water and collected by suction filtration.

Quelle