Reaktion #2160903

Reaktionsgleichung

potassium hydroxide

hydroxylamine hydrochloride

2-(diethylamino)-1-(naphthalen-1-yl)ethanone

→

title compound

2-(Diethylamino)-1-(naphthalen-1-yl)ethanone oxime

Lösungsmittel

methanol

water

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture is concentrated in vacuo
2. 2
   ExtraktionAdd methylene chloride and extract with 3×200 mL of water
3. 3
   TrocknenDry the organic layer over sodium sulfate
4. 4
   SonstigeRemove the solvent in vacuo

Vorschrift

To a cooled solution of 97.6 g (1.48 mol) of potassium hydroxide in 320 mL of methanol add a solution of 20.8 g (0.3 mol) of hydroxylamine hydrochloride in 48 mL of water at 20° C. To this basic solution add a solution of 16 g (0.064 mol) of 2-(diethylamino)-1-(naphthalen-1-yl)ethanone in 20.8 mL of methanol at 20° C. Stir the reaction mixture overnight. The reaction mixture is concentrated in vacuo. Add methylene chloride and extract with 3×200 mL of water. Dry the organic layer over sodium sulfate. Remove the solvent in vacuo to obtain the title compound.

Quelle