Reaktion #215925

Reaktionsgleichung

4-hydroxy-3-methoxybenzaldehyde

1-methyl hydantoin

β-alanine

acetic acid

→

product

Ausbeute 14.8%

5- [(4-Hydroxy-3-methoxyphenyl )methylene ]-1-methyl-2,4imidazolidinedione

Ausbeute 14.8%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated to reflux
2. 2
   Filtrationthe precipitate filtered off
3. 3
   Waschenrinsed successively with water (3X), ethanol (2X), and ether (2X)
4. 4
   Sonstigedried
5. 5
   SonstigeRecrystallization from acetonitrile

Vorschrift

A mixture of 4-hydroxy-3-methoxybenzaldehyde (4.6 g, 30 mmoles), 1-methyl hydantoin (3.5 g, 30 mmoles), β-alanine (1.4 g, 16 mmoles), and acetic acid (40 ml) is stirred under an inert atmosphere and heated to reflux. After 8 hours the mixture is stirred into water (300 ml) and the precipitate filtered off, rinsed successively with water (3X), ethanol (2X), and ether (2X), and dried. Recrystallization from acetonitrile gave the pure product (1.1 g), mp 197°-198° C.

Quelle