Reaktion #215917

Reaktionsgleichung

4-hydroxy-3-methoxybenzaldehyde

hydantoin

β-alanine

acetic acid

→

product

Ausbeute 42.7%

5- [(4-Hydroxy-3-methoxyphenyl )methylene ]-2,4-imidazolidinedione

Ausbeute 42.7%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated to reflux
2. 2
   Filtrationthe precipitate is filtered off
3. 3
   Waschenrinsed successively with water (3X), ethanol (2X), and ether (2X)
4. 4
   Sonstigedried
5. 5
   SonstigeRecrystallization from methanol

Vorschrift

A mixture of 4-hydroxy-3-methoxybenzaldehyde (4.6 g, 30 mmoles), hydantoin (3.0 g, 30 mmoles), β-alanine (1.4 g, 16 mmoles), and acetic acid (40 ml) is stirred under an inert atmosphere and heated to reflux. After 4 hours the mixture is stirred into water (350 ml) and the precipitate is filtered off, rinsed successively with water (3X), ethanol (2X), and ether (2X), and dried. Recrystallization from methanol afforded the pure product (3.0 g), mp 272°-273° C.

Quelle