Reaktion #215771

Reaktionsgleichung

2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid

Thionyl chloride

→

2-methoxy-4-(1-Boc-4-piperidyloxy)benzoyl chloride

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo

Vorschrift

2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid (3.2 g, 9.1 mmol) was dissolved in THF (35 ml). Thionyl chloride (1 ml, 1.63 g, 13.7 mmol) was added dropwise, followed by 2 drops of pyridine. The mixture was stirred at ambient temperature under nitrogen for 4.5 hours, then concentrated in vacuo. The residue was reconcentrated from ether to give 2-methoxy-4-(1-Boc-4-piperidyloxy)benzoyl chloride.

Quelle